Depression is the most common mental health disorder affecting adolescents and adults in the United States. The purpose of this study was to explore the relationships among depressive symptoms and college students' self-reported quality of personal relationships with parents and peers. There were no statistically significant gender differences in quality of relationship with parents, but there were differences with peers. The spirituality analysis suggested that a higher level of spirituality was related to better quality of personal relationships as well as fewer depressive symptoms. There were significant differences in depressive symptoms among various ethnicities in this sample. Future research with a larger, more ethnically diverse sample would be beneficial, and spirituality needs further exploration to confirm significance.